Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.54 |
| ▸ | BACE1 | P56817 | 5/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275856 | 0.86 | CASP1 (0.49) | RENBACE1BACE2CASP1 | |
| SCHEMBL7275894 | 0.86 | BACE1 (0.50) | RENBACE1BACE2CASP1 | |
| SCHEMBL7287204 | 0.86 | CASP1 (0.49) | RENBACE1BACE2CASP1 | |
| SCHEMBL7284988 | 0.86 | CASP1 (0.49) | RENBACE1BACE2CASP1 | |
| SCHEMBL30008729 | 0.79 | CASP1 (0.59) | RENBACE1BACE2CASP1 | |
| SCHEMBL7277216 | 0.77 | BACE1 (0.58) | RENBACE1BACE2CASP1 | |
| SCHEMBL7277693 | 0.76 | BACE1 (0.58) | RENBACE1BACE2CASP1 | |
| SCHEMBL7285134 | 0.76 | BACE1 (0.59) | RENBACE1BACE2CASP1 | |
| SCHEMBL5689425 | 0.76 | CASP1 (0.49) | RENBACE1BACE2CASP1 | |
| SCHEMBL7747439 | 0.76 | BACE1 (0.57) | RENBACE1BACE2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519748-B1 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO INC (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5434248-A | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0519748-A2 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO. INC. (US) | 1992-12-23 | — | — | EP | disclosed |