Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 12/20 | 0.60 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | PREP | P48147 | 2/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305436 | 0.93 | CMA1 (0.65) | CMA1ELANECTSL | |
| SCHEMBL8366717 | 0.93 | CMA1 (0.65) | CMA1ELANECTSL | |
| SCHEMBL31185247 | 0.92 | CMA1 (0.52) | CMA1CTSLCTSBPREP | |
| SCHEMBL3469545 | 0.90 | PREP (0.65) | CMA1ELANECTSLPREP | |
| SCHEMBL10416187 | 0.90 | PREP (0.65) | CMA1ELANECTSLPREP | |
| SCHEMBL30051146 | 0.90 | ALDH1A1 (0.62) | CMA1CAPN1ELANECTSLCTSB | |
| SCHEMBL1506200 | 0.90 | ALDH1A1 (0.62) | CMA1CAPN1ELANECTSLCTSB | |
| SCHEMBL22209363 | 0.90 | ALDH1A1 (0.62) | CMA1CAPN1ELANECTSLCTSB | |
| SCHEMBL12023625 | 0.90 | ALDH1A1 (0.53) | CMA1ELANECTSLPREP | |
| SCHEMBL478151 | 0.90 | ALDH1A1 (0.53) | CMA1ELANECTSLPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6054593-A | Proline derivatives | ZENECA LIMITED (GB) | 2000-04-25 | — | — | US | disclosed |
| US-6048889-A | Proline derivatives | ZENECA LIMITED (GB) | 2000-04-11 | — | — | US | disclosed |
| US-6037363-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 2000-03-14 | — | — | US | disclosed |
| US-5907068-A | TRIFLUOROMETHYLSUBSTITUTED COMPOUND INCLUDED IN PEPTIDES | ZENECA INC. (US) | 1999-05-25 | — | — | US | disclosed |
| US-5907043-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 1999-05-25 | — | — | US | disclosed |
| US-5808097-A | OXIDATION OF THE CORRESPONDING HYDROXY COMPOUND | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| US-5739157-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |
| US-5726158-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE USEFUL IN TREATING TISSUE DEGENERATIVE DISEASES; TRIFLUOROMETHYL KETONE SUBSTITUTED DI-, TRI-, AND TETRA-PEPTIDE DERIVATIVES | ZENECA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5686628-A | Proline derivatives | ZENECA LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0743953-A1 | DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LIMITED (GB) | 1996-11-27 | — | — | EP | disclosed |
| US-4923890-A | Difluoro keto compounds and their use as HLE inhibitors | ICI AMERICAS INC. (US) | 1990-05-08 | — | — | US | disclosed |
| US-4910190-A | Containing a nitrogen containing heterocycle ring structure | ICI AMERICAS INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4880780-A | RESPIRATORY SYSTEM DISORDERS | ICI AMERICAS INC. (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| EP-0249349-A1 | Difluoroketo compounds | ICI AMERICAS INC. (US) | 1987-12-16 | — | — | EP | disclosed |
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0204571-A2 | Selected difluoro derivatives | ICI AMERICAS INC. (US) | 1986-12-10 | — | — | EP | disclosed |
| EP-0189305-A2 | Peptide derivatives | ICI AMERICAS INC. (US) | 1986-07-30 | — | — | EP | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |