Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285283 | 1.00 | KDM4E (0.41) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL7285389 | 0.79 | JAK2 (0.38) | KDM4EALDH1A1JAK2BTKMEN1 | |
| SCHEMBL839 | 0.77 | MAPK1 (0.52) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL838 | 0.77 | MAPK1 (0.52) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL7294032 | 0.72 | BCHE (0.49) | — | |
| SCHEMBL7433263 | 0.71 | KMT2A (0.43) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL7433257 | 0.71 | KMT2A (0.43) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL5415870 | 0.70 | HSD17B10 (0.46) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL5415867 | 0.70 | HSD17B10 (0.46) | KDM4EMAPTMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL7285339 | 0.69 | BRD4 (0.42) | JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |