Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31547358 | 1.00 | MAOA (0.54) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL720132 | 0.92 | NR4A1 (0.58) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL716024 | 0.89 | NR4A1 (0.61) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9796939 | 0.87 | NR4A1 (0.58) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20769259 | 0.86 | ALDH1A1 (0.58) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL720131 | 0.84 | GAA (0.52) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7284080 | 0.82 | NR4A1 (0.48) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7285325 | 0.82 | MAOA (0.55) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7283647 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7292290 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353032-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS | Sankyo Company Limited (JP) | 1992-02-26 | — | — | EP | disclosed |
| US-5002942-A | Calcium channel blockers for cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1991-03-26 | — | — | US | disclosed |
| EP-0353032-A1 | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |