Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285997 | 1.00 | ALDH1A1 (0.47) | ALDH1A1HTTTP53RAB9AKDM4E | |
| SCHEMBL17532412 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HTTTP53RAB9AL3MBTL1 | |
| SCHEMBL10883243 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HTTTP53RAB9AKDM4E | |
| SCHEMBL17532416 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTRAB9ALMNATDP1 | |
| SCHEMBL29024787 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTTP53RAB9AKDM4E | |
| SCHEMBL1101920 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTTP53RAB9AKDM4E | |
| SCHEMBL29322878 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTTP53RAB9AKDM4E | |
| SCHEMBL10869246 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTTP53RAB9AKDM4E | |
| SCHEMBL1147308 | 0.71 | ALDH1A1 (0.48) | ALDH1A1HTTTP53RAB9AL3MBTL1 | |
| SCHEMBL17532423 | 0.71 | ALDH1A1 (0.49) | ALDH1A1HTTTP53RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |