Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 4/20 | 0.56 |
| ▸ | BACE1 | P56817 | 4/20 | 0.56 |
| ▸ | BCHE | P06276 | 3/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402993 | 0.86 | KDM4E (0.67) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL7840653 | 0.82 | GAA (0.68) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL7286551 | 0.81 | KDM4E (0.74) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL7297024 | 0.81 | KDM4E (0.60) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL5671677 | 0.80 | KDM4E (0.70) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL28332709 | 0.80 | KDM4E (0.70) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL7289451 | 0.80 | KDM4E (0.70) | KDM4EGAAMAPK1ACHEBACE1 | |
| Hydrochloric Acid SCHEMBL11102409 | 0.79 | KDM4E (0.68) | KDM4EGAAMAPK1ACHEBACE1 | |
| SCHEMBL444689 | 0.77 | KDM4E (0.62) | KDM4EGAAMAPK1ROCK2ROCK1 | |
| SCHEMBL918426 | 0.77 | KDM4E (0.66) | KDM4EGAAMAPK1ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |