Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | TYK2 | P29597 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6161250 | 0.85 | KDM4E (0.60) | KDM4EGAAMAPK1SIGMAR1POLB | |
| SCHEMBL6153601 | 0.84 | KDM4E (0.62) | KDM4EGAAMAPK1JAK2JAK1 | |
| SCHEMBL12279961 | 0.82 | JAK2 (0.61) | KDM4EGAAMAPK1JAK2JAK1 | |
| SCHEMBL3994220 | 0.81 | KDM4E (0.55) | KDM4EGAAMAPK1SIGMAR1POLB | |
| SCHEMBL6154811 | 0.80 | SLC6A12 (0.56) | KDM4ESIGMAR1HSD17B10DRD4KCNH2 | |
| SCHEMBL6154543 | 0.80 | SLC6A12 (0.59) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL6155299 | 0.80 | JAK2 (0.53) | JAK2JAK1TYK2JAK3SIGMAR1 | |
| SCHEMBL6153502 | 0.80 | OPRK1 (0.59) | KDM4EGAAMAPK1SIGMAR1DRD4 | |
| SCHEMBL6157012 | 0.80 | OPRK1 (0.56) | KDM4EGAAMAPK1SIGMAR1DRD4 | |
| SCHEMBL22605677 | 0.80 | JAK2 (0.50) | KDM4EJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160108020-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-21 | — | — | US | disclosed |
| US-9255080-B2 | Quinazolinedione derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-09 | — | — | US | disclosed |
| US-20140100239-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-10 | — | — | US | disclosed |
| US-8623884-B2 | Quinazolinedione derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2014-01-07 | — | — | US | disclosed |
| US-20120065216-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | KENNIS LUDO EDMOND JOSEPHINE (BE) | 2012-03-15 | — | — | US | disclosed |
| US-8080557-B2 | Quinazolinedione derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2011-12-20 | — | — | US | disclosed |
| CN-1980913-B | quinazolinedione derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-12-14 | — | — | CN | disclosed |
| US-20090253727-A1 | NOCICEPTIN ANALOGS | PURDUE PHARMA L.P. (US) | 2009-10-08 | — | — | US | disclosed |
| US-7563809-B2 | Nociceptin analogs | PURDUE PHARMA, L.P. (US) | 2009-07-21 | — | — | US | disclosed |
| US-20080039480-A1 | Quinazolinedione Derivatives as Parp Inhibitors | JANSSEN PHARMCEUTICA, NV (BE) | 2008-02-14 | — | — | US | disclosed |
| CN-1980913-A | Quinazolinedione derivatives as parp inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-13 | — | — | CN | disclosed |
| EP-1763523-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006003148-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-12 | — | — | WO | disclosed |
| WO-2006003148-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108020-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP3 | KDM4E 1577/4885GAA 2500/4885MAPK1 1548/4885 |
| US-20080039480-A1 | Quinazolinedione Derivatives as Parp Inhibitors | PARP1, PARP2, PARP3 | KDM4E 1577/4885GAA 2500/4885MAPK1 1548/4885 |
| US-20090253727-A1 | NOCICEPTIN ANALOGS | OPRL1, NPBWR1, OPRK1 | KDM4E 4526/4885GAA 3721/4885MAPK1 3563/4885 |
| US-20120065216-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP3 | KDM4E 1577/4885GAA 2500/4885MAPK1 1548/4885 |
| US-20140100239-A1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP3 | KDM4E 1577/4885GAA 2500/4885MAPK1 1548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.