Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6860344 | 1.00 | ELANE (0.39) | ELANELMNASMN1; SMN2HTTMAPT | |
| SCHEMBL7286221 | 0.88 | KMT2A (0.43) | ELANEMAPTMAPK1KMT2AMEN1 | |
| SCHEMBL7278964 | 0.87 | KMT2A (0.41) | ELANEALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL6860338 | 0.77 | ELANE (0.51) | ELANEKMT2AHCRTR1HCRTR2 | |
| SCHEMBL7279611 | 0.77 | ELANE (0.34) | ELANEKMT2A | |
| SCHEMBL7286678 | 0.75 | PTPN2 (0.35) | ELANESMN1; SMN2ALDH1A1KMT2AHCRTR1 | |
| SCHEMBL7279276 | 0.75 | ELANE (0.37) | ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL7279242 | 0.75 | LMNA (0.33) | ELANELMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6588427 | 0.74 | ELANE (0.33) | ELANELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7276813 | 0.73 | ELANE (0.43) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |