Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294825 | 1.00 | DRD2 (0.56) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7286300 | 1.00 | DRD2 (0.56) | DRD2DRD3MAPTLMNAADRA2A | |
| Hydrochloric Acid SCHEMBL7293712 | 0.99 | MAPT (0.57) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7291765 | 0.85 | DRD2 (0.53) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7291768 | 0.85 | DRD2 (0.53) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7284189 | 0.84 | DRD2 (0.52) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7284182 | 0.84 | DRD2 (0.52) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7285804 | 0.84 | LMNA (0.60) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7285808 | 0.84 | LMNA (0.60) | DRD2DRD3MAPTLMNAADRA2A | |
| SCHEMBL7294700 | 0.84 | LMNA (0.60) | DRD2DRD3MAPTLMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347766-B1 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | THOMAE GMBH DR K (DE) | 1994-05-25 | — | — | EP | disclosed |
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |