SCHEMBL7286371

SCHEMBL7286371

CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(C(=O)Cc2ccc(N)cc2)c1=O)C(=O)C(F)(F)F

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 0.71
CTRC Q99895 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7283633 0.99 ELANE (0.70) ELANECTRC
SCHEMBL7276963 0.88 ELANE (0.64) ELANE
Hydrochloric Acid SCHEMBL9011726 0.86 ELANE (0.87) ELANECTRC
SCHEMBL7274370 0.83 ELANE (1.00) ELANECTRC
SCHEMBL7450541 0.82 ELANE (0.89) ELANE
SCHEMBL7286325 0.81 ELANE (0.81) ELANECTRC
SCHEMBL7431953 0.81 ELANE (0.71) ELANE
SCHEMBL7284369 0.80 ELANE (1.00) ELANECTRC
SCHEMBL7273489 0.80 ELANE (1.00) ELANECTRC
SCHEMBL7436613 0.80 ELANE (0.89) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0509769-B1 Heterocyclic amides having HLE inhibiting activity ZENECA LTD (GB) 1996-09-11 EP claimed
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 US claimed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 EP claimed