Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.43 |
| ▸ | PREP | P48147 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284719 | 0.99 | ITGB3 (0.43) | ITGB3ITGA2BPREPSIGMAR1KLK7 | |
| SCHEMBL8619569 | 0.98 | SIGMAR1 (0.44) | ITGB3ITGA2BPREPSIGMAR1 | |
| SCHEMBL7285021 | 0.98 | SIGMAR1 (0.44) | ITGB3ITGA2BPREPSIGMAR1 | |
| SCHEMBL7311516 | 0.95 | ITGB3 (0.46) | ITGB3ITGA2BPREPSIGMAR1MAPT | |
| SCHEMBL7333560 | 0.89 | ITGB3 (0.43) | ITGB3ITGA2BPREPSIGMAR1KLK7 | |
| SCHEMBL7286805 | 0.89 | PREP (0.43) | ITGB3ITGA2BPREPSIGMAR1KLK7 | |
| SCHEMBL7296887 | 0.89 | PREP (0.43) | ITGB3ITGA2BPREPSIGMAR1KLK7 | |
| SCHEMBL7295402 | 0.89 | MAPT (0.42) | ITGB3ITGA2BPREPSIGMAR1KLK7 | |
| SCHEMBL7359899 | 0.89 | ITGB3 (0.46) | ITGB3ITGA2BPREP | |
| SCHEMBL8553717 | 0.88 | ITGB3 (0.51) | ITGB3ITGA2BPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822931-B1 | PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-27 | — | — | EP | disclosed |
| US-6020334-A | Piperazinones, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-01 | — | — | US | disclosed |
| US-5935963-A | (4-GUANIDINOBENZOYLAMINO)ACETYL-3-(3-(4-GUANIDINOBENZOYLAMINO) PROPYL)-2-OXOPIPERAZINE-1-ACETIC ACID OR A SALT; CONTROLLING OR INHIBITING CELL-ADHESION; PLATELET ANTIAGGREGATION WITHOUT LONG HEMORRHAGING; ANTIICHEMIC AGENTS; ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1999-08-10 | — | — | US | disclosed |
| US-5888531-A | ACTIVE MATERIAL STABILIZED WITH DISACCHARIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-30 | — | — | US | disclosed |
| US-5876756-A | SUSTAINED RELEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-02 | — | — | US | disclosed |
| EP-0822931-A1 | PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION | Takeda Chemical Industries, Ltd. (JP) | 1998-02-11 | — | — | EP | disclosed |
| EP-0765660-A2 | Microcapsules comprising 2-piperazinone-1-acetic acid compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-02 | — | — | EP | disclosed |
| EP-0750913-A2 | Disaccharide containing freeze-dried preparation for pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-02 | — | — | EP | disclosed |
| WO-1996033982-A1 | PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |