Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 12/20 | 0.47 |
| ▸ | GZMB | P10144 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556934 | 1.00 | CASP1 (0.47) | CASP1GZMBCASP3 | |
| SCHEMBL5085996 | 1.00 | CASP1 (0.47) | CASP1GZMBCASP3 | |
| SCHEMBL2556937 | 1.00 | CASP1 (0.47) | CASP1GZMBCASP3 | |
| SCHEMBL20257122 | 0.92 | CASP1 (0.49) | CASP1CASP3 | |
| SCHEMBL20257125 | 0.92 | CASP1 (0.49) | CASP1CASP3 | |
| SCHEMBL23133189 | 0.92 | CASP1 (0.49) | CASP1CASP3 | |
| SCHEMBL23133187 | 0.92 | CASP1 (0.49) | CASP1CASP3 | |
| SCHEMBL7275397 | 0.88 | CASP1 (0.41) | CASP1GZMBCASP3 | |
| SCHEMBL14345603 | 0.84 | CAPN1 (0.40) | CASP1 | |
| SCHEMBL7285000 | 0.82 | CASP1 (0.64) | CASP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519748-A2 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO. INC. (US) | 1992-12-23 | — | — | EP | claimed |
| EP-0519748-B1 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO INC (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5434248-A | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0519748-A2 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO. INC. (US) | 1992-12-23 | — | — | EP | disclosed |