Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287171 | 1.00 | LMNA (0.52) | LMNAHTTKMT2AMEN1CYP1A2 | |
| SCHEMBL7285761 | 0.92 | SMN1; SMN2 (0.52) | LMNAHTTKMT2AMEN1CYP1A2 | |
| SCHEMBL7285760 | 0.92 | SMN1; SMN2 (0.52) | LMNAHTTKMT2AMEN1CYP1A2 | |
| SCHEMBL7286482 | 0.89 | KMT2A (0.55) | LMNAHTTKMT2AMEN1CYP1A2 | |
| SCHEMBL7286486 | 0.89 | KMT2A (0.55) | LMNAHTTKMT2AMEN1CYP1A2 | |
| SCHEMBL7286627 | 0.84 | KMT2A (0.47) | LMNAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7286633 | 0.84 | KMT2A (0.47) | LMNAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7284217 | 0.80 | KMT2A (0.52) | LMNAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7284221 | 0.80 | KMT2A (0.52) | LMNAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7289041 | 0.79 | L3MBTL1 (0.53) | LMNAKMT2AMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810220-B1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |