Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.62 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.62 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.62 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.62 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284871 | 0.95 | GRIN2D (0.58) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7289245 | 0.88 | GRIN2D (0.79) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL6207982 | 0.87 | GRIN2D (0.78) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7286160 | 0.86 | GRIN2B (0.69) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7287485 | 0.85 | GRIN2B (0.67) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7294406 | 0.84 | MAPT (0.56) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7285720 | 0.83 | GRIN2D (0.55) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7296447 | 0.83 | MAPT (0.55) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7285242 | 0.83 | MAPT (0.54) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7286173 | 0.81 | LTA4H (0.67) | GRIN2DGRIN3BMAPTGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |