Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.67 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.67 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294820 | 0.94 | KDM4E (0.64) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| SCHEMBL6208225 | 0.93 | GRIN2D (0.62) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| SCHEMBL7289245 | 0.93 | GRIN2D (0.79) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| SCHEMBL7295960 | 0.93 | GRIN2D (0.65) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| SCHEMBL6207318 | 0.92 | GRIN2D (0.78) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| Hydrochloric Acid SCHEMBL6207982 | 0.92 | GRIN2D (0.78) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| SCHEMBL6207626 | 0.92 | GRIN2D (0.65) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| Hydrochloric Acid SCHEMBL6207785 | 0.91 | GRIN2D (0.76) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| Hydrochloric Acid SCHEMBL6208483 | 0.91 | GRIN2D (0.64) | LTA4HGRIN2DGRIN3BMAPTGRIN1 | |
| SCHEMBL7290504 | 0.87 | KDM4E (0.57) | LTA4HGRIN2DGRIN3BMAPTGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |