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SCHEMBL7287684

SCHEMBL7287684

CCCC[C@H](NC(=O)C(C)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(C)C)[C@@H](O)CC(C(=O)NCC(C)C)C(C)O

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 2/20 0.47
▸ REN P00797 16/20 0.46
▸ PSMB5 P28074 1/20 0.42
▸ ANPEP P15144 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7292837 0.90 BACE1 (0.49) BACE1RENPSMB5
SCHEMBL7294736 0.89 BACE1 (0.48) BACE1REN
Hydrochloric Acid SCHEMBL7286804 0.89 BACE1 (0.48) BACE1RENPSMB5
SCHEMBL7425967 0.88 BACE1 (0.48) BACE1REN
Hydrochloric Acid SCHEMBL7287504 0.88 BACE1 (0.48) BACE1REN
Hydrochloric Acid SCHEMBL7295948 0.88 BACE1 (0.47) BACE1REN
SCHEMBL7428760 0.88 BACE1 (0.47) BACE1REN
Hydrochloric Acid SCHEMBL7431404 0.87 BACE1 (0.46) BACE1REN
SCHEMBL7428494 0.78 BACE1 (0.45) BACE1REN
SCHEMBL7295725 0.78 REN (0.48) BACE1REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0264106-A2 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use Banyu Pharmaceutical Co., Ltd. (JP) 1988-04-20 — — EP claimed
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