Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6441220 | 1.00 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL9272290 | 0.95 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL6443766 | 0.95 | LMNA (0.61) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL6440409 | 0.95 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL18222653 | 0.95 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| Tridecan-1-Ol SCHEMBL28159549 | 0.92 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL3089826 | 0.92 | LMNA (0.65) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL20943397 | 0.92 | LMNA (0.64) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL6446817 | 0.92 | SMN1; SMN2 (0.58) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL1100934 | 0.92 | SMN1; SMN2 (0.58) | ALDH1A1SMN1; SMN2LMNATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0602814-A1 | Crystal forms of optically active isoindolines and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| US-5273978-A | 1-Oxo-2-(7-chloro-1,8-naphthyridin-2-yl)-3-(4-oxypiperidino -carbonylmethylene)isoindolines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-28 | — | — | US | disclosed |
| EP-0529778-A1 | Optically active isoindoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |