Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 3/20 | 0.38 |
| ▸ | GSTM2 | P28161 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288363 | 0.85 | GSTP1 (0.52) | TDP1GPR35CA12GSTP1GSTM2 | |
| SCHEMBL4770160 | 0.76 | ALDH1A1 (0.45) | TDP1GPR35CA12TSHRALDH1A1 | |
| SCHEMBL4767130 | 0.75 | ALDH1A1 (0.39) | TDP1GPR35CA12TSHRALDH1A1 | |
| SCHEMBL7297148 | 0.74 | GPR35 (0.45) | TDP1GPR35CA12GSTP1GSTM2 | |
| SCHEMBL15452483 | 0.73 | TDP1 (0.52) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7287483 | 0.72 | CYP3A4 (0.41) | TDP1GSTP1GSTM2TSHRALDH1A1 | |
| SCHEMBL7292079 | 0.72 | SMN1; SMN2 (0.33) | TDP1TSHRALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7354205 | 0.71 | MAPT (0.53) | TDP1ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL8672345 | 0.70 | GSTP1 (0.54) | TDP1GSTP1GSTM2TSHRALDH1A1 | |
| SCHEMBL9204285 | 0.69 | SCN4A (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |