Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.60 |
| ▸ | PDE4A | P27815 | 14/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637207 | 1.00 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7278320 | 1.00 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7270844 | 1.00 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7278324 | 1.00 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL4637716 | 0.93 | ALDH1A1 (0.55) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL4637257 | 0.92 | ALDH1A1 (0.54) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7373523 | 0.84 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7367183 | 0.84 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7364734 | 0.83 | ALDH1A1 (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7364522 | 0.80 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428302-B1 | Enzymatic resolution of endo-bicycle(2.2.1)-heptan-2-ol and derived pharmaceutical agents | PFIZER (US) | 1997-09-24 | — | — | EP | claimed |
| US-5270206-A | Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents | PFIZER INC. (US) | 1993-12-14 | — | — | US | claimed |
| US-5461056-A | Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders | PFIZER INC. (US) | 1995-10-24 | — | — | US | disclosed |
| US-5395935-A | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents | PFIZER INC. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5342842-A | Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders | PFIZER INC. (US) | 1994-08-30 | — | — | US | disclosed |
| US-5270206-A | Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents | PFIZER INC. (US) | 1993-12-14 | — | — | US | disclosed |
| WO-1991007501-A1 | ENZYMATIC RESOLUTION OF ENDO-BICYCLO[2.2.1]HEPTAN-2-OL AND DERIVED PHARMACEUTICAL AGENTS | PFIZER INC. (US) | 1991-05-30 | — | — | WO | disclosed |