Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.48 |
| ▸ | ABAT | P80404 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 11/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637207 | 0.83 | PDE4B (0.60) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7288403 | 0.83 | PDE4B (0.60) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7270844 | 0.83 | PDE4B (0.60) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7278320 | 0.83 | PDE4B (0.60) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7278324 | 0.83 | PDE4B (0.60) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7373523 | 0.80 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7367183 | 0.80 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7363090 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL6142798 | 0.77 | ALDH1A1 (0.46) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3844120 | 0.76 | ALDH1A1 (0.59) | ALDH1A1TRIM24HPGDALDH5A1ABAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |