Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288468 | 0.88 | MEN1 (0.56) | TSHRMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL7288616 | 0.85 | CYP2D6 (0.65) | L3MBTL1TSHRUSP2MAPTMEN1 | |
| SCHEMBL7288741 | 0.83 | USP2 (0.65) | L3MBTL1TSHRUSP2MAPTMEN1 | |
| SCHEMBL7283526 | 0.83 | L3MBTL1 (0.60) | L3MBTL1TSHRUSP2MEN1KMT2A | |
| SCHEMBL7288432 | 0.82 | MEN1 (0.69) | L3MBTL1TSHRMAPTMEN1KMT2A | |
| SCHEMBL7281277 | 0.81 | KMT2A (0.60) | L3MBTL1TSHRMAPTMEN1KMT2A | |
| SCHEMBL7296395 | 0.81 | MAPT (0.66) | L3MBTL1TSHRUSP2MAPTMEN1 | |
| SCHEMBL10835718 | 0.81 | USP2 (0.64) | TSHRUSP2MAPTMEN1KMT2A | |
| SCHEMBL7281988 | 0.80 | MEN1 (0.59) | TSHRMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL7281560 | 0.79 | NPSR1 (0.55) | TSHRUSP2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |