Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288616 | 0.91 | CYP2D6 (0.65) | MAPTKMT2AMEN1L3MBTL1TSHR | |
| SCHEMBL7281277 | 0.88 | KMT2A (0.60) | MAPTKMT2AMEN1L3MBTL1TSHR | |
| SCHEMBL7288741 | 0.86 | USP2 (0.65) | MAPTKMT2AMEN1L3MBTL1TSHR | |
| SCHEMBL7288432 | 0.82 | MEN1 (0.69) | MAPTKMT2AMEN1L3MBTL1TSHR | |
| SCHEMBL7279511 | 0.82 | CYP2D6 (0.59) | MAPTKMT2AMEN1TSHRGAA | |
| SCHEMBL10835718 | 0.81 | USP2 (0.64) | MAPTKMT2AMEN1TSHRUSP2 | |
| SCHEMBL10835709 | 0.81 | CYP2D6 (0.66) | KMT2AMEN1L3MBTL1CYP2D6MAPK1 | |
| SCHEMBL7289903 | 0.81 | TP53 (0.57) | MAPTKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7288404 | 0.81 | L3MBTL1 (0.55) | MAPTKMT2AMEN1L3MBTL1TSHR | |
| SCHEMBL7288820 | 0.81 | CYP2D6 (0.64) | MAPTKMT2AMEN1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |