Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289945 | 0.84 | LMNA (0.54) | LMNATP53PDE4APDE4BPDE4C | |
| SCHEMBL7282870 | 0.82 | PDE4B (0.46) | LMNATP53PDE4APDE4BPDE4C | |
| SCHEMBL7289643 | 0.80 | PDE4A (0.59) | LMNATP53PDE4APDE4BPDE4C | |
| SCHEMBL7291550 | 0.77 | KMT2A (0.58) | LMNAALDH1A1KDM4EGAAHPGD | |
| SCHEMBL7288541 | 0.76 | ALDH1A1 (0.46) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7291924 | 0.74 | PDE4A (0.52) | LMNATP53PDE4APDE4BPDE4C | |
| SCHEMBL7282267 | 0.73 | GAA (0.41) | LMNATP53PDE4APDE4BPDE4C | |
| SCHEMBL7281409 | 0.73 | KMT2A (0.52) | LMNAALDH1A1KDM4ESMN1; SMN2DRD2 | |
| SCHEMBL7289446 | 0.72 | PDE4A (0.53) | LMNAPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7288081 | 0.71 | PDE4A (0.52) | LMNAPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4505910-A | Amino-pyrimidine derivatives, compositions and use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-19 | — | — | US | claimed |
| EP-0130735-A1 | Amino-pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-01-09 | — | — | EP | claimed |
| US-4505910-A | Amino-pyrimidine derivatives, compositions and use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-19 | — | — | US | disclosed |
| EP-0130735-A1 | Amino-pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-01-09 | — | — | EP | disclosed |