Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RNF4 | P78317 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 9/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14704320 | 0.93 | GAA (0.56) | GAAL3MBTL1ALDH1A1POLBRNF4 | |
| SCHEMBL31022551 | 0.87 | GAA (0.67) | GAAL3MBTL1ALDH1A1POLBFAAH | |
| SCHEMBL29270204 | 0.87 | POLB (0.77) | ALDH1A1POLBRNF4HTTKDM4E | |
| SCHEMBL9390735 | 0.85 | L3MBTL1 (0.74) | GAAL3MBTL1ALDH1A1POLBFAAH | |
| SCHEMBL14702216 | 0.85 | MAPT (0.55) | GAAL3MBTL1ALDH1A1FAAHHTT | |
| SCHEMBL4543223 | 0.84 | POLB (0.65) | GAAL3MBTL1ALDH1A1POLBFAAH | |
| SCHEMBL8693936 | 0.84 | GAA (0.63) | GAAL3MBTL1ALDH1A1POLBFAAH | |
| SCHEMBL4423437 | 0.83 | GAA (0.70) | GAAL3MBTL1FAAHMAPT | |
| SCHEMBL10957894 | 0.82 | RNF4 (0.52) | GAAL3MBTL1ALDH1A1POLBRNF4 | |
| SCHEMBL6692679 | 0.82 | CA12 (0.58) | GAAL3MBTL1ALDH1A1POLBFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |