Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288640 | 1.00 | PTGIR (0.51) | PTGIRLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL7288649 | 1.00 | PTGIR (0.51) | PTGIRLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL7290617 | 1.00 | PTGIR (0.51) | PTGIRLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL844128 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL8564803 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL8566029 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL4673678 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL844722 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL6631278 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL1713427 | 0.78 | LMNA (0.55) | LMNASMN1; SMN2HTTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928793-B1 | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | EP | disclosed |
| US-6001855-A | REACTING A THIAZOLE DERIVATIVE AND A CYCLIC AMINE DERIVATIVE; INHIBITS BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES OF CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS | HOFFMAN-LA ROCHE INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0928793-A1 | Thiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-07-14 | — | — | EP | disclosed |