Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279246 | 0.90 | MAPT (0.52) | KDM4ESTAT3HIF1AMAPTTSHR | |
| SCHEMBL7279023 | 0.83 | KDM4E (0.47) | SMN1; SMN2GAACYP1A2KDM4EMAPT | |
| SCHEMBL20944057 | 0.80 | KDM4E (0.49) | SMN1; SMN2GAACYP1A2KDM4ESTAT3 | |
| SCHEMBL22116876 | 0.79 | KDM4E (0.47) | SMN1; SMN2CYP1A2KDM4ESTAT3HIF1A | |
| SCHEMBL29070876 | 0.79 | KDM4E (0.47) | SMN1; SMN2CYP1A2KDM4ESTAT3HIF1A | |
| SCHEMBL4886365 | 0.78 | GAA (0.43) | SMN1; SMN2GAACYP1A2KDM4EELANE | |
| SCHEMBL1368157 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2GAACYP1A2KDM4EMEN1 | |
| SCHEMBL22094261 | 0.77 | GAA (0.56) | SMN1; SMN2GAACYP1A2KDM4EHIF1A | |
| SCHEMBL22116806 | 0.76 | KDM4E (0.45) | SMN1; SMN2CYP1A2KDM4ESTAT3HIF1A | |
| SCHEMBL5750893 | 0.75 | BRD4 (0.53) | SMN1; SMN2KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904675-A | Phamacologically active 5-carboxy-2-(5-tetrazolyl) pyridines | ZYMA SA (CH) | 1990-02-27 | — | — | US | disclosed |
| EP-0278908-A2 | Heterocyclic compounds | Zyma SA (CH) | 1988-08-17 | — | — | EP | disclosed |