Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | SHBG | P04278 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GABRP | O00591 | 2/20 | 0.52 |
| ▸ | GABRD | O14764 | 2/20 | 0.52 |
| ▸ | G6PD | P11413 | 2/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22675087 | 0.84 | LMNA (0.64) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL23265362 | 0.84 | LMNA (0.64) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8499073 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL15426615 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL25854513 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6812901 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL7376650 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6812905 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6816494 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL19750469 | 0.80 | LMNA (0.69) | LMNAGPBAR1CYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825197-B1 | New 6-hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 2000-10-04 | — | — | EP | disclosed |
| US-5914324-A | HYPOTENSIVE AGENTS, TREATMENT OF CARDIAC FAILURE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1999-06-22 | — | — | US | disclosed |
| EP-0825197-A2 | New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1998-02-25 | — | — | EP | disclosed |