Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289022 | 1.00 | F2 (0.30) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7288780 | 0.83 | — | — | |
| SCHEMBL7282774 | 0.79 | — | — | |
| SCHEMBL7282769 | 0.79 | — | — | |
| SCHEMBL3466455 | 0.73 | ALDH1A1 (0.38) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7282278 | 0.73 | MMP3 (0.50) | — | |
| SCHEMBL7282283 | 0.73 | MMP3 (0.50) | — | |
| SCHEMBL7279289 | 0.72 | — | — | |
| SCHEMBL7279285 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL5498553 | 0.72 | ALDH1A1 (0.36) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742069-A | CALCIUM ANTAGONIST, ANTIANGINA, ANTIISCHEMIC, HYPOTENSIVE | HOFFMANN-LA ROCHE INC. (US) | 1988-05-03 | — | — | US | disclosed |
| EP-0166422-A1 | Dihydropyridine derivatives, processes and intermediates for their preparation and pharmaceutical preparations containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-01-02 | — | — | EP | disclosed |