Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571135 | 0.83 | PDE3A (0.38) | PDE3APDE3BHRH3KCNH2KDM4E | |
| SCHEMBL10569366 | 0.83 | HRH3 (0.38) | GPR119PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7298104 | 0.80 | PDE3A (0.42) | GPR119PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL10585131 | 0.79 | GALR3 (0.39) | PDE3APDE3BHRH3KCNH2ALDH1A1 | |
| SCHEMBL10341530 | 0.77 | HRH3 (0.53) | GPR119PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7294824 | 0.77 | PDE3B (0.50) | PDE3APDE3BKDM4EALDH1A1MAPT | |
| SCHEMBL10341592 | 0.75 | PDE3B (0.55) | GPR119PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7297883 | 0.71 | PBRM1 (0.40) | PDE3APDE3BHRH3KCNH2ALDH1A1 | |
| SCHEMBL10563541 | 0.70 | VHL (0.41) | GPR119PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL10559741 | 0.70 | PDE3A (0.37) | PDE3APDE3BHRH3KCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0281045-A1 | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |