Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571135 | 0.85 | PDE3A (0.38) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL7289484 | 0.83 | GPR119 (0.38) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL7298104 | 0.82 | PDE3A (0.42) | HRH3KCNH2PDE3APDE3BPBRM1 | |
| SCHEMBL10585131 | 0.81 | GALR3 (0.39) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL7294824 | 0.78 | PDE3B (0.50) | PDE3APDE3BMAPTDDB1CRBN | |
| SCHEMBL9602068 | 0.75 | HRH3 (0.57) | HRH3KCNH2PDE3APDE3BMAPT | |
| Hydrochloric Acid SCHEMBL7314082 | 0.74 | HRH3 (0.56) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL10341487 | 0.73 | PDE3B (0.57) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL7297883 | 0.73 | PBRM1 (0.40) | HRH3KCNH2PDE3APDE3BPBRM1 | |
| SCHEMBL7290530 | 0.72 | PDE4A (0.38) | MAPTPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |