Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378157 | 0.76 | PDE3A (0.35) | PBRM1PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL10571135 | 0.73 | PDE3A (0.38) | PBRM1PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7298498 | 0.72 | PDE3A (0.32) | PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7289484 | 0.71 | GPR119 (0.38) | PBRM1PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7288859 | 0.70 | PDE3A (0.39) | PBRM1PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL10585131 | 0.69 | GALR3 (0.39) | PDE3APDE3BHRH3KCNH2MAPK1 | |
| SCHEMBL7290309 | 0.69 | ALDH1A1 (0.41) | MAPK1HTTALDH1A1NPC1RAB9A | |
| SCHEMBL7294824 | 0.67 | PDE3B (0.50) | PDE3APDE3BMAPK1ALDH1A1NPC1 | |
| SCHEMBL7292775 | 0.67 | HRH3 (0.34) | PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL7286897 | 0.66 | POLB (0.43) | ALDH1A1NPC1RAB9APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426018-B1 | Thiophene compounds and their pharmaceutical uses | YOSHITIOMI PHARMACEUTICAL IND (JP) | 1997-08-27 | — | — | EP | disclosed |
| EP-0729960-A1 | Thiophene compounds and their use as intermediates in the preparation of antianxiety drugs, hypnotics, antiepileptic drugs and nuotropics | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-09-04 | — | — | EP | disclosed |
| US-5329016-A | Antianxiety, hypnotic agents, antiepileptic agents or nootropics | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| US-5175162-A | Anxiolytic, antiepilepic agents | YOSHITIOMI PHARMACEUTICAL INDUSTRIES LTD. (JP) | 1992-12-29 | — | — | US | disclosed |
| EP-0426018-A2 | Thiophene compounds and their pharmaceutical uses | YOSHITIOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |