Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289755 | 0.91 | ROCK2 (0.45) | HDAC1NAMPTL3MBTL1NR1H4UBE2N | |
| SCHEMBL7282483 | 0.86 | NAMPT (0.43) | HDAC1NAMPTL3MBTL1TDP1MAPT | |
| SCHEMBL7282966 | 0.86 | NAMPT (0.41) | HDAC1NAMPTL3MBTL1TDP1MAPT | |
| SCHEMBL8663875 | 0.81 | HDAC1 (0.46) | HDAC1NAMPTL3MBTL1TDP1MAPT | |
| SCHEMBL8925502 | 0.80 | ROCK2 (0.44) | HDAC1L3MBTL1MAPTUBE2NMEN1 | |
| SCHEMBL7292267 | 0.80 | SMPD1 (0.47) | HDAC1MAPTHDAC6UBE2NMEN1 | |
| SCHEMBL7289312 | 0.79 | PTPRC (0.41) | HDAC1MAPTMEN1KMT2A | |
| SCHEMBL9221746 | 0.79 | NAMPT (0.57) | HDAC1NAMPTL3MBTL1NR1H4HDAC6 | |
| SCHEMBL20328570 | 0.77 | SMPD1 (0.48) | HDAC1MAPTHDAC6HDAC10MEN1 | |
| SCHEMBL7549497 | 0.76 | HDAC1 (0.44) | HDAC1NAMPTL3MBTL1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981531-A | FOR INHIBITING PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1999-11-09 | — | — | US | disclosed |
| EP-0632016-B1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LTD (GB) | 1997-04-09 | — | — | EP | disclosed |
| US-5612373-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1997-03-18 | — | — | US | disclosed |
| WO-1995000472-A1 | 1,2 DIACYLATED HYDRAZINE DERIVATIVES AND THEIR USE AS ALL ADHESION INHIBITORS | ZENECA LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |
| EP-0632016-A1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |