Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.65 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.65 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.65 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.65 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.65 |
| ▸ | LTA4H | P09960 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286173 | 0.93 | LTA4H (0.67) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7289245 | 0.91 | GRIN2D (0.79) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL6207982 | 0.90 | GRIN2D (0.78) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL6208225 | 0.89 | GRIN2D (0.62) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7297969 | 0.89 | GRIN2B (0.82) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7393665 | 0.87 | GRIN2B (0.80) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7294820 | 0.87 | KDM4E (0.64) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL6207318 | 0.86 | GRIN2D (0.78) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL6207626 | 0.86 | GRIN2D (0.65) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL6207785 | 0.85 | GRIN2D (0.76) | GRIN2DGRIN3BMAPTGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |