Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.52 |
| ▸ | MMP9 | P14780 | 6/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299611 | 0.88 | ALDH1A1 (0.54) | MMP2MMP9ADAMTS4ALDH1A1MEN1 | |
| SCHEMBL7406797 | 0.81 | ALDH1A1 (0.54) | MMP2MMP9ALDH1A1MEN1KMT2A | |
| SCHEMBL7406800 | 0.81 | ALDH1A1 (0.54) | MMP2MMP9ALDH1A1MEN1KMT2A | |
| SCHEMBL4698163 | 0.80 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL4698160 | 0.80 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL8683934 | 0.80 | ALDH1A1 (0.58) | MMP2MMP9ADAMTS4ALDH1A1MEN1 | |
| SCHEMBL7439451 | 0.79 | TSHR (0.47) | MMP2MMP9ALDH1A1MEN1KMT2A | |
| SCHEMBL7436034 | 0.77 | MEN1 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL25386615 | 0.76 | POLB (0.56) | MMP2MMP9ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL7299545 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288851-A | Reacting two equivalents of sulfamyl chloride with one of amino acid in inorganic aqueous base and water miscible organic solvent, coupling product with peptide fragment | WARNER-LAMBERT COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| US-5162527-A | Peptides | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |
| US-5063207-A | Cardiovascular disorders | WARNER-LAMBERT COMPANY (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0389535-A1 | RENIN INHIBITORS, PROCESSES FOR PREPARING THEM, METHODS FOR USING THEM, AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1990-10-03 | — | — | EP | disclosed |
| WO-1989003841-A1 | RENIN INHIBITORS, PROCESSES FOR PREPARING THEM, METHODS FOR USING THEM, AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0314060-A2 | Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |