Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297228 | 1.00 | PDE3B (1.00) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL11018276 | 0.81 | PDE3B (0.67) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL11018273 | 0.81 | PDE3B (0.67) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL11017552 | 0.79 | PDE3B (0.65) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL11017553 | 0.79 | PDE3B (0.65) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL10972483 | 0.78 | PTGS1 (0.68) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11015933 | 0.77 | SMN1; SMN2 (0.62) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL11015932 | 0.77 | SMN1; SMN2 (0.62) | PDE3BPDE3ALMNAPDE4APDE4B | |
| Imazodan SCHEMBL148436 | 0.76 | PDE3B (1.00) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL7280332 | 0.76 | PDE3B (1.00) | PDE3BPDE3ALMNAPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | claimed |
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | claimed |
| JP-60166679-A | — | — | None | — | — | JP | disclosed |
| US-4656170-A | CARDIOTONIC, HYPOTENSIVE, ANTITHROMBOTIC | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| JP-S60166679-A | 4,5-DIHYDRO-6-(2-(4-(1H-IMIDAZOL-1-YL)PHENYL)-ETHENYL)-3(2H)-PYRIDAZINONES AND RELATED COMPOUNDS | WARNER LAMBERT CO | 1985-08-29 | — | — | JP | disclosed |
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |