Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015932 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A | |
| SCHEMBL11020084 | 0.81 | RAB9A (0.45) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A | |
| SCHEMBL11020085 | 0.81 | RAB9A (0.45) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A | |
| SCHEMBL11021347 | 0.80 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A | |
| SCHEMBL11021355 | 0.80 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A | |
| SCHEMBL11015670 | 0.78 | PDE3B (0.66) | SMN1; SMN2PDE3BPDE3AMAOBCYP17A1 | |
| SCHEMBL11015667 | 0.78 | PDE3B (0.66) | SMN1; SMN2PDE3BPDE3AMAOBCYP17A1 | |
| SCHEMBL7280036 | 0.77 | PDE3B (0.59) | PDE3BPDE3ACYP3A4BAZ2BMEN1 | |
| SCHEMBL7290070 | 0.77 | PDE3B (1.00) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A | |
| SCHEMBL7297228 | 0.77 | PDE3B (1.00) | SMN1; SMN2RAB9ANPC1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |