Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | MME | P08473 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10756689 | 0.86 | CTNNB1 (0.50) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL10477757 | 0.86 | CTNNB1 (0.47) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL9194477 | 0.82 | CPA1 (0.57) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL10338654 | 0.82 | CPA1 (0.57) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL3814684 | 0.82 | CTNNB1 (0.56) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL7429100 | 0.82 | CPA1 (0.57) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL9554930 | 0.82 | MME (0.48) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL9554924 | 0.82 | MME (0.48) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL6677809 | 0.81 | CTNNB1 (0.63) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL7310334 | 0.81 | NPC1 (0.48) | CTNNB1TDP1HRH4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |