Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.51 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PAM | P19021 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317629 | 0.85 | MTNR1A (0.69) | MTNR1AMTNR1BPRNPNPSR1RXFP1 | |
| SCHEMBL4542367 | 0.85 | MTNR1A (0.69) | MTNR1AMTNR1BPRNPNPSR1RXFP1 | |
| SCHEMBL7250898 | 0.82 | PPARA (0.57) | ANPEP | |
| SCHEMBL5228193 | 0.82 | PPARA (0.57) | ANPEP | |
| SCHEMBL7289392 | 0.82 | PPARA (0.57) | ANPEP | |
| SCHEMBL27218106 | 0.82 | PRNP (0.49) | MTNR1AMTNR1BPRNPNPSR1RXFP1 | |
| SCHEMBL27218104 | 0.82 | PRNP (0.49) | MTNR1AMTNR1BPRNPNPSR1RXFP1 | |
| SCHEMBL11552778 | 0.81 | MTNR1A (0.54) | MTNR1AMTNR1BPRNPNPSR1RXFP1 | |
| SCHEMBL30354385 | 0.81 | PRNP (0.46) | MTNR1AMTNR1BPRNPNPSR1RXFP1 | |
| SCHEMBL5226937 | 0.80 | PPARA (0.55) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5905077-A | Inhibitors of HIV protease useful for the treatment of AIDS | ELI LILLY AND COMPANY (US) | 1999-05-18 | — | — | US | disclosed |
| EP-0604185-B1 | Inhibitors of HIV protease useful for the treatment of AIDS | LILLY CO ELI (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5733906-A | Inhibitors of HIV Protease useful for the treatment of Aids | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0604185-A1 | Inhibitors of HIV protease useful for the treatment of aids | ELI LILLY AND COMPANY (US) | 1994-06-29 | — | — | EP | disclosed |