SCHEMBL7290458

SCHEMBL7290458

CC1(C)C[CH]c2cccc(C(F)(F)F)c2O1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.35
TRPV1 Q8NER1 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7290795 0.78 HTR2C (0.42)
SCHEMBL7293354 0.78 HTR2C (0.42)
SCHEMBL7299519 0.77 LMNA (0.32) KMT2A
SCHEMBL9583841 0.76 HTR2C (0.43)
SCHEMBL7300630 0.75 HTR1A (0.33)
SCHEMBL7298517 0.74 KMT2A (0.31) KMT2A
SCHEMBL15075070 0.71 KMT2A (0.40) KMT2ATRPV1
SCHEMBL7290461 0.70 KMT2A (0.37) KMT2ATRPV1
SCHEMBL2319912 0.69 KMT2A (0.41) KMT2ATRPV1
SCHEMBL3322442 0.68 TRPV1 (0.43) KMT2ATRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5260444-A Cardiovascular, hypotensive WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1993-11-09 US disclosed
US-5208245-A Hypotensive agents WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1993-05-04 US disclosed
EP-0460418-A2 Novel Dihydropyridine derivative WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1991-12-11 EP disclosed