Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | AQP1 | P29972 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540030 | 0.94 | KDM4E (0.55) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL11540442 | 0.84 | KDM4E (0.56) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11538214 | 0.83 | KDM4E (0.58) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL11539001 | 0.82 | KDM4E (0.57) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11541800 | 0.81 | CA2 (0.38) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11540082 | 0.81 | KDM4E (0.56) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11538413 | 0.81 | KDM4E (0.53) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11121179 | 0.79 | KDM4E (0.51) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11540200 | 0.79 | KDM4E (0.54) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11541795 | 0.79 | CA2 (0.37) | KDM4EUSP2ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011818-B1 | MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE | CIBA-GEIGY AG (CH) | 1983-01-19 | — | — | EP | claimed |
| US-4261985-A | REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | claimed |
| EP-0011818-A1 | Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | claimed |
| EP-0165902-B1 | EPOXY STEROIDS | CIBA-GEIGY AG (CH) | 1989-04-19 | — | — | EP | disclosed |
| US-4670551-A | ALDOSTERONE ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0165902-A2 | Epoxy steroids | CIBA-GEIGY AG (CH) | 1985-12-27 | — | — | EP | disclosed |
| US-4559332-A | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof | CIBA GEIGY CORPORATION (US) | 1985-12-17 | — | — | US | disclosed |
| US-4552871-A | ALDOSTERONE-ANTAGONISTIC, DIURETICS | CIBA GEIGY CORPORATION (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0122882-A1 | Steroids of the 20-spiroxan series, process for their preparation, pharmaceutical compositions containing them and use of these compositions | CIBA-GEIGY AG (CH) | 1984-10-24 | — | — | EP | disclosed |
| EP-0122232-A1 | 20-Spiroxanes and analogues with open ring E, process for their preparation and pharmaceutical compositions | CIBA-GEIGY AG (CH) | 1984-10-17 | — | — | EP | disclosed |
| EP-0011818-B1 | MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE | CIBA-GEIGY AG (CH) | 1983-01-19 | — | — | EP | disclosed |
| US-4261985-A | REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0011818-A1 | Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | disclosed |
| US-4176190-A | Diuretic and saliuretic sulphamoylbenzoic acids | CIBA-GEIGY CORPORATION (US) | 1979-11-27 | — | — | US | disclosed |