Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCH | P24723 | 4/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282692 | 0.88 | SMN1; SMN2 (0.47) | PRKCHPRKCEPRKCDPRKCQPDE3B | |
| SCHEMBL11234893 | 0.87 | PDE3B (0.49) | PRKCQROCK1PDE3BPDE3ACYP2C19 | |
| SCHEMBL7291227 | 0.86 | ALDH1A1 (0.49) | PRKCDPRKCAPDE3BPDE3ACYP2C19 | |
| SCHEMBL11251403 | 0.81 | PDE3B (0.50) | PDE3BPDE3ACYP2C19KDM4EPDE5A | |
| SCHEMBL7291097 | 0.80 | SMN1; SMN2 (0.48) | PDE3BPDE3ACYP2C19KDM4EPDE5A | |
| SCHEMBL7298318 | 0.80 | CNR1 (0.47) | PDE3BPDE3ACYP2C19KDM4EPDE5A | |
| SCHEMBL29409515 | 0.76 | PDE3B (0.51) | PDE3BPDE3ACYP2C19KDM4EPDE5A | |
| SCHEMBL7284439 | 0.76 | PRKCH (0.46) | PRKCHPRKCEPRKCDROCK2PRKCB | |
| SCHEMBL7291890 | 0.76 | CYP1A2 (0.58) | CYP2C19KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL7291760 | 0.74 | CYP1A2 (0.56) | CYP2C19KDM4ELMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |