Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | MMP9 | P14780 | 11/20 | 0.63 |
| ▸ | MMP2 | P08253 | 10/20 | 0.63 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125448 | 0.86 | NR3C1 (1.00) | NR3C1 | |
| SCHEMBL3575003 | 0.83 | NR3C1 (0.77) | NR3C1MMP2MMP1MMP14 | |
| SCHEMBL3123139 | 0.82 | NR3C2 (0.73) | NR3C1MMP9MMP2KMT2AMEN1 | |
| SCHEMBL3123148 | 0.82 | NR3C2 (0.73) | NR3C1MMP9MMP2KMT2AMEN1 | |
| SCHEMBL30006844 | 0.82 | NR3C2 (0.73) | NR3C1MMP9MMP2KMT2AMEN1 | |
| SCHEMBL3134951 | 0.82 | NR3C2 (0.73) | NR3C1MMP9MMP2KMT2AMEN1 | |
| SCHEMBL5191094 | 0.81 | MMP9 (0.89) | MMP9MMP2KMT2AMEN1POLB | |
| SCHEMBL6720186 | 0.81 | MMP9 (0.89) | MMP9MMP2KMT2AMEN1POLB | |
| SCHEMBL8448692 | 0.80 | MMP9 (0.71) | NR3C1MMP9MMP2KMT2AMEN1 | |
| SCHEMBL8448689 | 0.80 | MMP9 (0.71) | NR3C1MMP9MMP2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763436-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5595999-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5583133-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5532232-A | INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD | HOFFMANN-LA ROCHE INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0468231-B1 | Guanidins | HOFFMANN LA ROCHE (CH) | 1994-09-21 | — | — | EP | disclosed |
| US-5260307-A | Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma | HOFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0468231-A2 | Guanidins | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-29 | — | — | EP | disclosed |