Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 5/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646130 | 1.00 | FBP1 (0.65) | FBP1PRMT1AKR1C3RECQLALDH1A1 | |
| SCHEMBL7299178 | 1.00 | FBP1 (0.65) | FBP1PRMT1AKR1C3RECQLALDH1A1 | |
| SCHEMBL11140787 | 0.85 | FBP1 (0.58) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| SCHEMBL6382677 | 0.85 | FBP1 (0.58) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| SCHEMBL42324 | 0.85 | FBP1 (0.58) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| SCHEMBL27897016 | 0.83 | FBP1 (0.56) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| SCHEMBL27867388 | 0.83 | FBP1 (0.56) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| SCHEMBL27883556 | 0.83 | FBP1 (0.56) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL4989759 | 0.83 | FBP1 (0.56) | FBP1PRMT1AKR1C3SMN1; SMN2HTT | |
| SCHEMBL11360465 | 0.82 | FBP1 (0.56) | FBP1PRMT1AKR1C3RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164010-B1 | 3-NITRO-DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | BAYER AG (DE) | 1989-02-22 | — | — | EP | claimed |
| EP-0139859-B1 | 1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | BAYER AG (DE) | 1988-10-19 | — | — | EP | claimed |
| EP-0164010-A2 | 3-Nitro-dihydropyridines, process for their preparation and their pharmaceutical use | BAYER AG (DE) | 1985-12-11 | — | — | EP | claimed |
| EP-0139859-A2 | 1,4-Dihydropyridines, method for their preparation and their use as medicaments | BAYER AG (DE) | 1985-05-08 | — | — | EP | claimed |
| CN-102603534-A | New process for synthesizing p-nitrobenzaldehyde | ZHENGMING ZHANG | 2012-07-25 | — | — | CN | disclosed |
| CN-102190536-A | Method for organically catalyzing asymmetric conjugated addition of ketene and organic phosphorus compound | UNIV EAST CHINA SCIENCE & TECH | 2011-09-21 | — | — | CN | disclosed |
| EP-0347678-B1 | 1,4-Dihydropyridine threonin derivatives and process for their preparation | BAYER AG (DE) | 1997-02-26 | — | — | EP | disclosed |
| EP-0628538-B1 | Process for the acylation of threonine derivatives and their use in the preparation of 1,4-dihydropyridines | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0628538-A1 | Process for the acylation of threonine derivatives and their use in the preparation of 1,4-dihydropyridines | BAYER AG (DE) | 1994-12-14 | — | — | EP | disclosed |
| US-5138091-A | Chemical intermediate | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0308785-B1 | DIHYDROPYRIDINE ETHERS, PROCESSES FOR THEIR PREPARATION AND THEIR UTILISATION | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| US-5017590-A | 1,4-dihydropyridine-threonine compounds with cardiovascular activity | BAYER AKTIENGESELLSCHAFT (DE) | 1991-05-21 | — | — | US | disclosed |
| EP-0164010-A2 | 3-Nitro-dihydropyridines, process for their preparation and their pharmaceutical use | BAYER AG (DE) | 1985-12-11 | — | — | EP | disclosed |
| US-4537881-A | 5-Nitro 1,4-dihydropyridines having a positive inotropic effect | BAYER AKTIENGESELLSCHAFT (DE) | 1985-08-27 | — | — | US | disclosed |
| EP-0139859-A2 | 1,4-Dihydropyridines, method for their preparation and their use as medicaments | BAYER AG (DE) | 1985-05-08 | — | — | EP | disclosed |
| EP-0139859-A2 | 1,4-Dihydropyridines, method for their preparation and their use as medicaments | BAYER AG (DE) | 1985-05-08 | — | — | EP | disclosed |
| EP-0034349-B1 | NOVEL PYRIDINECARBOXAMIDE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, THE USE OF SAID DERIVATIVES AND A PHARMACEUTICAL COMPOSITION CONTAINING SAME | Tanabe Seiyaku Co., Ltd. (JP) | 1983-12-14 | — | — | EP | disclosed |
| US-4332809-A | ANTIALLERGENS | TANABE SEIYAKU CO., LTD. (JP) | 1982-06-01 | — | — | US | disclosed |
| EP-0034349-A2 | Novel pyridinecarboxamide derivatives, a process for the preparation thereof, the use of said derivatives and a pharmaceutical composition containing same | Tanabe Seiyaku Co., Ltd. (JP) | 1981-08-26 | — | — | EP | disclosed |
| US-4248873-A | Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-03 | — | — | US | disclosed |