Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 14/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | PPARG | P37231 | 9/20 | 0.65 |
| ▸ | PPARA | Q07869 | 5/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | PPARD | Q03181 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6105957 | 0.88 | NR1H4 (0.78) | NR1H4NPC1ALDH1A1GLARAB9A | |
| SCHEMBL5226864 | 0.87 | NR1H4 (0.77) | NR1H4PPARGPPARAPPARD | |
| SCHEMBL7302098 | 0.86 | PDCD1 (0.68) | NR1H4NPC1ALDH1A1GLARAB9A | |
| SCHEMBL4831403 | 0.86 | NR1H4 (0.67) | NR1H4NPC1ALDH1A1GLARAB9A | |
| SCHEMBL15176770 | 0.86 | NPC1 (0.68) | NR1H4NPC1ALDH1A1GLARAB9A | |
| SCHEMBL15233661 | 0.85 | POLB (0.62) | NR1H4ALDH1A1RAB9AATMMAPT | |
| SCHEMBL6108092 | 0.85 | TSHR (0.72) | NR1H4NPC1ALDH1A1GLARAB9A | |
| SCHEMBL29050680 | 0.84 | RAB9A (0.64) | NR1H4NPC1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL5223315 | 0.83 | RAB9A (0.73) | NR1H4NPC1ALDH1A1GLARAB9A | |
| SCHEMBL29903436 | 0.83 | NR1H4 (0.74) | NR1H4PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |
| EP-0358118-B1 | Phenylamides - process for their preparation as well as a drug containing those compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| US-5135949-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0358118-A1 | Phenylamides - process for their preparation as well as a drug containing those compounds | Roche Diagnostics GmbH (DE) | 1990-03-14 | — | — | EP | disclosed |