SCHEMBL729232

SCHEMBL729232

c1ccc(Nc2ncco2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 1/20 0.46
FLT4 P35916 1/20 0.46
KDR P35968 1/20 0.46
PIN1 Q13526 1/20 0.45
RAB9A P51151 4/20 0.44
NPC1 O15118 3/20 0.44
MAPT P10636 3/20 0.44
MAPK1 P28482 2/20 0.44
CHEK1 O14757 1/20 0.44
IKBKB O14920 1/20 0.44
AURKA O14965 1/20 0.44
PDPK1 O15530 1/20 0.44
CHEK2 O96017 1/20 0.44
PRKCG P05129 1/20 0.44
CDK1 P06493 1/20 0.44
LYN P07948 1/20 0.44
KIT P10721 1/20 0.44
PIM1 P11309 1/20 0.44
FGFR1 P11362 1/20 0.44
FGFR3 P22607 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4532117 0.78 EGFR (0.50) KDRAURKA
SCHEMBL544111 0.78 MEN1 (0.50) KDRMAPTCDK2ALDH1A1GAA
SCHEMBL30041659 0.77 EPHX2 (0.48) FLT1KDRCDK2GSK3BEPHX2
SCHEMBL543837 0.77 HDAC3 (0.42) KDRRAB9ANPC1MAPTMAPK1
SCHEMBL8598939 0.76 MEN1 (0.53) KDRRAB9ANPC1PIM1ATM
SCHEMBL28928918 0.76 KDR (0.36) KDRTSHR
SCHEMBL6237657 0.76 AURKA (0.57) RAB9AMAPTMAPK1AURKAALDH1A1
SCHEMBL6253671 0.75 IDO1 (0.44) AURKA
SCHEMBL17186347 0.74 SMN1; SMN2 (0.57) KDRRAB9ANPC1AURKAPIM1
SCHEMBL544110 0.73 NPC1 (0.44) RAB9ANPC1AURKACSNK2A1ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160000815-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS GOSFORTH CT HOLDINGS PTY LTD (AU) 2016-01-07 US claimed
US-20140142140-A1 PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD (AU) 2014-05-22 US claimed
EP-2729216-A1 PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS Gosforth Centre (Holdings) Pty Ltd (AU) 2014-05-14 EP claimed
WO-2013007698-A1 PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD (AU) 2013-01-17 WO claimed
JP-2011529923-A 2011-12-15 JP claimed
US-20110207718-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD. (AU) 2011-08-25 US claimed
EP-2331088-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS Gosforth Centre (Holdings) Pty Ltd (AU) 2011-06-15 EP claimed
EP-2035436-B1 FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA SA (BE) 2011-05-25 EP claimed
WO-2010015029-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD (AU) 2010-02-11 WO claimed
WO-2025125248-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS THAT OVEREXPRESS TSPAN1 FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA (ES) 2025-06-19 WO disclosed
CN-119833780-A Zinc cathode gel electrolyte integrated structure, preparation method thereof and zinc ion battery 深圳北理莫斯科大学 2025-04-15 CN disclosed
CN-118043318-A Novel compound for capping layer and organic light-emitting element comprising same 株式会社东进世美肯 2024-05-14 CN disclosed
CN-116157399-A Novel compound for capping layer and organic light-emitting element comprising same 东进世美肯株式会社 2023-05-23 CN disclosed
EP-4178576-A1 DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS Emergent Product Development Gaithersburg Inc. (US) 2023-05-17 EP disclosed
CN-1109024-C Fluoric derivative of N-phenyl-2-oxazolylamine (thiazolylamine) and its preparing process and application HUADONG SCIENCE & ENGINEERING (CN) 2003-05-21 CN disclosed
WO-2003040141-A1 OXAZOLYL-PHENYL-2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2003-05-15 WO disclosed
CN-1294126-A Fluoric derivative of N-phenyl-2-oxazolylamine (thiazolylamine) and its preparing process and application HUADONG SCIENCE & ENGINEERING (CN) 2001-05-09 CN disclosed
CN-1294126-A Fluoric derivative of N-phenyl-2-oxazolylamine (thiazolylamine) and its preparing process and application HUADONG SCIENCE & ENGINEERING (CN) 2001-05-09 CN disclosed
EP-1034176-A1 THIOPHENE-SULFONAMIDE COMPOUNDS PHARMACIA & UPJOHN S.p.A. (IT) 2000-09-13 EP disclosed
WO-1999028316-A1 THIOPHENE-SULFONAMIDE COMPOUNDS PHARMACIA & UPJOHN S.P.A. (IT) 1999-06-10 WO disclosed