Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 4/20 | 0.30 |
| ▸ | MMP9 | P14780 | 3/20 | 0.30 |
| ▸ | MMP7 | P09237 | 2/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288590 | 0.96 | CTSD (0.30) | CTSD | |
| SCHEMBL7270971 | 0.79 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7299395 | 0.78 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7290039 | 0.71 | MMP1 (0.32) | CTSDMMP1MMP9MMP7MMP3 | |
| SCHEMBL7282942 | 0.71 | MMP1 (0.32) | CTSDMMP1MMP9MMP7MMP3 | |
| SCHEMBL8908550 | 0.70 | KDM6B (0.32) | CTSDMMP1MMP9MMP7MMP3 | |
| SCHEMBL7270999 | 0.70 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL9417461 | 0.70 | KDM6B (0.32) | CTSDMMP1MMP9MMP7MMP3 | |
| SCHEMBL9222144 | 0.70 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 | |
| SCHEMBL7292526 | 0.70 | MMP1 (0.31) | MMP1MMP9MMP7MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5442044-A | Hypotensive agents | PFIZER INC. (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0661292-A1 | Orally active renin inhibitors | PFIZER INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| EP-0438233-A2 | Orally active renin inhibitors | PFIZER INC. (US) | 1991-07-24 | — | — | EP | disclosed |