Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018591 | 0.80 | GAA (0.65) | GAAHPGDALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL503977 | 0.80 | GAA (0.65) | GAAHPGDALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL624930 | 0.79 | SMN1; SMN2 (0.61) | HPGDALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL4355417 | 0.79 | HPGDS (0.55) | HPGDALDH1A1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL21755483 | 0.79 | MEN1 (0.63) | HPGDALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL29799615 | 0.79 | SMN1; SMN2 (0.61) | HPGDALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL3465985 | 0.79 | HPGDS (0.55) | HPGDALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4654289 | 0.79 | GAA (0.63) | GAAHPGDALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL23888902 | 0.78 | HPGDS (0.54) | HPGDALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL31605249 | 0.78 | HPGDS (0.54) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166609-A2 | Aryl derivatives of heterobicyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-01-02 | — | — | EP | disclosed |