Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297137 | 0.88 | NPC1 (0.48) | POLBELANERAB9ANPC1MAOB | |
| SCHEMBL8401233 | 0.86 | POLB (0.53) | HDAC3HDAC1HDAC2POLBELANE | |
| SCHEMBL7294413 | 0.83 | NAMPT (0.47) | HDAC3HDAC1HDAC2POLBELANE | |
| SCHEMBL7292947 | 0.82 | ELANE (0.45) | POLBELANERAB9ANPC1MAOB | |
| SCHEMBL8405741 | 0.82 | TRPV1 (0.48) | POLBELANERAB9ANPC1MAOB | |
| SCHEMBL8403664 | 0.82 | SCD (0.48) | POLBELANERAB9ANPC1MAOB | |
| SCHEMBL8405275 | 0.81 | NPC1 (0.53) | POLBELANERAB9ANPC1MAOB | |
| SCHEMBL8401497 | 0.81 | NPC1 (0.47) | POLBELANERAB9ANPC1MAOB | |
| SCHEMBL8401151 | 0.80 | ELANE (0.46) | POLBELANERAB9ANPC1MAPT | |
| SCHEMBL7296472 | 0.79 | ELANE (0.43) | HDAC3HDAC1HDAC2POLBELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |