Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 5/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297137 | 0.94 | NPC1 (0.48) | NPC1RAB9APOLBSMN1; SMN2ELANE | |
| SCHEMBL8401497 | 0.91 | NPC1 (0.47) | TRPV1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL8401151 | 0.90 | ELANE (0.46) | NPC1RAB9APOLBSMN1; SMN2ELANE | |
| SCHEMBL7292947 | 0.90 | ELANE (0.45) | NPC1RAB9APOLBSMN1; SMN2ELANE | |
| SCHEMBL8403664 | 0.90 | SCD (0.48) | TRPV1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL8401233 | 0.90 | POLB (0.53) | TRPV1NPC1RAB9APOLBELANE | |
| SCHEMBL8405275 | 0.87 | NPC1 (0.53) | TRPV1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL7294413 | 0.87 | NAMPT (0.47) | TRPV1NPC1RAB9APOLBELANE | |
| SCHEMBL8405850 | 0.86 | ELANE (0.47) | NPC1RAB9APOLBELANE | |
| SCHEMBL7293123 | 0.82 | HDAC3 (0.44) | NPC1RAB9APOLBELANEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |