Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293139 | 1.00 | APP (0.51) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL9763203 | 0.90 | APP (0.51) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL450847 | 0.86 | HRH3 (0.52) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL450848 | 0.86 | HRH3 (0.52) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL7284483 | 0.84 | S1PR1 (0.48) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL7284489 | 0.84 | S1PR1 (0.48) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL8994528 | 0.80 | S1PR1 (0.47) | APPS1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL7370241 | 0.77 | S1PR1 (0.48) | S1PR1MEN1KMT2AS1PR3BCHE | |
| SCHEMBL7370240 | 0.77 | S1PR1 (0.48) | S1PR1MEN1KMT2AS1PR3BCHE | |
| SCHEMBL451121 | 0.76 | S1PR1 (0.61) | S1PR1MEN1KMT2AS1PR3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | claimed |
| EP-0537802-A2 | N-acylpyrrolidines and N-acylthiazolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-04-21 | — | — | EP | claimed |
| EP-0345428-A1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-13 | — | — | EP | claimed |